Publications by authors named "D Lagae"
Background: Early-life antibiotic exposure is disproportionately high compared to the burden of culture-proven early-onset sepsis (CP-EOS). We assessed the contribution of culture-negative cases to the overall antibiotic exposure in the first postnatal week.
Methods: We conducted a retrospective analysis across eleven countries in Europe, North America, and Australia.
Article Synopsis
- - Antibiotic use during infancy can disrupt the microbiome and contribute to higher antimicrobial resistance, which may lead to chronic health issues later on in life.
- - The main reason for excessive antibiotic treatment in newborns is the concern about potentially missing cases of neonatal sepsis.
- - The authors call for a more balanced approach that weighs the risks of overtreatment against the actual risks of disease, advocating for better management of antibiotics and sepsis care.
Importance: Appropriate use of antibiotics is life-saving in neonatal early-onset sepsis (EOS), but overuse of antibiotics is associated with antimicrobial resistance and long-term adverse outcomes. Large international studies quantifying early-life antibiotic exposure along with EOS incidence are needed to provide a basis for future interventions aimed at safely reducing neonatal antibiotic exposure.
Objective: To compare early postnatal exposure to antibiotics, incidence of EOS, and mortality among different networks in high-income countries.
Respiratory distress in newborn infants in Western Switzerland.
J Matern Fetal Neonatal Med
October 2021
Aim: To assess epidemiological data about respiratory distress (RD) in newborn infants hospitalized in Western Switzerland.
Methods: During 1 year, two questionnaires were sent out to the seven neonatal and pediatric units of a well-defined geographic region in Switzerland. Data about their obstetrical activity and details about all newborn infants hospitalized with RD were collected, asking for pre-, peri-, and postnatal clinical data in association with RD.
Enterovirus (EV) may cause a broad spectrum of clinical syndromes and even cause a sepsis-like picture. Although they are responsible for high morbidity and mortality rates, viral testing does not appear in the algorithms for the evaluation of neonatal infections. During the month of June 2013, we identified 3 cases of EV meningitis in our unit of neonatology.
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