Comparison of the efficacy of neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients: meta-analysis of randomized controlled trials.

Background: Preoperative neoadjuvant chemoradiotherapy (nCRT) is considered to be the standard treatment strategy for locally advanced rectal cancer (LARC); however, the risk of adverse events and postoperative recurrence remains significant. This study aimed to evaluate the non-inferiority of neoadjuvant chemotherapy (nCT) compared with nCRT in patients with LARC and to assess the possibility of eliminating radiotherapy on the basis of guaranteed efficacy.

Materials And Methods: We searched the PubMed, Embase, and Cochrane Library databases to identify randomized controlled trials (RCTs) comparing the efficacy of nCRT and nCT for LARC.

Association between sleep quality and serum biomarkers among long-term hot spring bathers: a cross-sectional study.

Previous studies investigating the influence of hot spring bathing on sleep quality have predominantly focused on the short-term effects through questionnaire surveys without blood collection for biochemical tests. Here, we undertook a comprehensive investigation of the long-term health effects of hot spring bathing among the residents of Hot Spring Village. A total of 140 participants were enrolled, and their demographic characteristics and the patterns of hot spring bathing were obtained via face-to-face interview, and sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI).

Total-solids-controlled microbial response and volatile fatty acids production in sludge and chicken manure co-fermentation.

With the aim of exploring the association between microbial response and volatile fatty acids (VFAs) production in sludge and chicken manure co-fermentation with total solids (TS) controlled, four fermentation experimental groups (TS = 20, 40, 60, and 80 g/L) were established in this study. The results demonstrated that the yield of VFAs reached the peak (530.08 mg COD/g VSS) at the 40 g-TS group.

Stress-Driven Production of γ-Aminobutyric Acid Using Non-Conventional Yeast Strains JMY140K and JMY075.

γ-Aminobutyric acid (GABA) is a valuable amino acid widely used in food, healthcare, and agriculture. GABA bioproduction by budding yeasts has been commonly reported, but related studies using non-conventional yeasts remain limited. In this study, two non-conventional natural yeast strains, namely, JMY140K and JMY075, were identified as promising GABA producers, and JMY075 was discovered to be a GABA producer.