Publications by authors named "D L Zanette"
Plant-based diets have been linked to various health benefits, including an improved gut microbiota composition, potentially influencing non-communicable diseases. This study investigates the impact of a school meal intervention on the gut microbiota, specifically the abundance of spp. (BIF), in Brazilian schoolchildren.
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- - Chronic myeloid leukemia (CML) is characterized by a specific genetic translocation (BCR::ABL1) that serves as a primary biomarker for diagnosis and prognosis, but research is exploring additional potential biomarkers like long noncoding RNAs (lncRNAs) and mRNAs.
- - A study utilizing RNA sequencing compared gene expression in 6 CML patients with high expression levels to 6 healthy individuals, followed by validation using RT-qPCR on samples from 87 CML patients and 42 healthy controls.
- - The findings indicated lower expression levels of certain genes in CML patients, and a relationship was observed where higher levels of one gene are linked to reduced expression of another in the context of treatment with imatin
Polymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: A meta-analysis of three large European cohorts and functional characterization.
Int J Cancer
January 2025
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with patients having unresectable or metastatic disease at diagnosis, with poor prognosis and very short survival. Given that genetic variation within autophagy-related genes influences autophagic flux and susceptibility to solid cancers, we decided to investigate whether 55,583 single nucleotide polymorphisms (SNPs) within 234 autophagy-related genes could influence the risk of developing PDAC in three large independent cohorts of European ancestry including 12,754 PDAC cases and 324,926 controls. The meta-analysis of these populations identified, for the first time, the association of the BID variant with an increased risk of developing the disease (OR = 1.
View Article and Find Full Text PDFUnlabelled: The progression of chronic obstructive pulmonary disease (COPD) is characterized by functional changes in the airways. The lung-gut axis and gut microbiota (GM) have been linked to the pathophysiology of airway diseases. Regarding COPD, studies have shown that GM alterations could be related the stages of this disease.
View Article and Find Full Text PDFBladder cancer (BC) is the second most common type of cancer of the urinary system. Approximately 75% of the cases are non-muscle invasive bladder cancer (NMIBC), which has a high recurrence and progression rate. Current diagnosis and surveillance methods present challenges, including risks to the patients.
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