Current status and future directions of application of urine proteomics in neonatology.

With continuous advancements in mass spectrometry technology, researchers increasingly utilize this method to investigate the molecular mechanisms underlying various diseases, and to identify novel diagnostic and therapeutic strategies. Among proteomics applications, urinary proteomics stands out for its non-invasive nature, making it particularly suitable for vulnerable populations like neonates. This review provides a comprehensive overview of recent research on urinary proteomics in the field of neonatology.

Cannabidiol Ameliorates Doxorubicin-Induced Myocardial Injury via Activating Hippo Pathway.

Background: Doxorubicin (DOX) is a chemotherapeutic agent widely used for cancer treatment and has non-negligible cardiotoxicity. Some previous studies have reported that cannabidiol (CBD) has cardioprotective effects. In this study, we evaluated the protective effects of CBD against DOX-induced cardiomyocyte injury, and explored the downstream molecular mechanism.

High operating temperature mid-wavelength infrared InAsSb nBn detectors and focal plane array.

Raising the operating temperature of mid-wavelength infrared detectors is critical for meeting the low size, weight, and power (SWaP) demands of infrared imaging systems. In this work, we report and analyze a high operating temperature (HOT) InAsSb nBn mid-wave infrared (MWIR) focal plane array (FPA) and single element photodetectors with AlAs/AlSb superlattices as the electron barrier. Under an applied bias of -350 mV, the nBn photodetectors demonstrate a dark current density of 2.

High efficiency and large angle polarization independent beam deflection metagrating by Bayesian optimization.

Directional emission sources are required in wide application scenarios such as 3D displays and optical communication. The integration of beam deflection metasurfaces on emission devices can construct a compact directional emission source. However, most reported metasurfaces and metagratings focus on the deflection of linear polarized light with relatively small angles(< 30 degrees), which limits their further application for unpolarized light sources.

Enhanced high brightness DBR tapered diode laser based on polarization match.

Tapered diode lasers, composed of an index-guided ridge waveguide and a gain-guided tapered amplifier, are affected by polarization mismatch between the ridge and tapered sections. Beam quality deterioration is caused by TM high-order modes generated in the ridge section. Under high current injection, these TM modes are further amplified in the tapered section due to polarization mismatch, leading to a decrease in the laser output brightness.