High-Resolution HLA-DRB1 Allele Frequencies in a Romanian Cohort of Stem Cell Donors.

The goal of the current study was to determine the high-resolution frequencies of the HLA-DRB1 alleles among the analyzed Romanian cohort of healthy stem cell donors. Using Next Generation Sequencing (NGS), we estimated class II HLA-DRB1 allele frequencies to a 6-digit resolution through HLA typing in a Romanian cohort of healthy individuals. The study for HLA genotyping included 420 willing donors from the National Registry of Voluntary Hematopoietic Stem Cell Donors (RNDVCSH).

Circulating tumor cells shed large extracellular vesicles in capillary bifurcations that activate endothelial and immune cells.

Circulating tumor cells (CTCs) and their clusters are the drivers of metastasis, but we have an incomplete understanding of how they interact with capillary beds. Using microfluidic models mimicking human capillary bifurcations, we observed cell size- and bifurcation-dependent shedding of nuclei-free fragments by patient CTCs, CTC-derived explant cells and numerous cancer cell lines. Shedding reduced cell sizes up to 61%, facilitating their transit through bifurcations.

Original Contributions to the Chemical Composition, Microbicidal, Virulence-Arresting and Antibiotic-Enhancing Activity of Essential Oils from Four Coniferous Species.

This study aimed to establish the essential oil (EO) composition from young shoots of , , , and harvested from Romania and evaluate their antimicrobial and anti-virulence activity, as well as potential synergies with currently used antibiotics. The samples' EO average content varied between 0.62% and 1.

[The role of the polimers in increased acrylic biomaterials qualities used in prosthetic restaurations].

Unlabelled: This study is aimed at the improvement of the biomaterials used in the field of entirely removable prosthesis quality. One important aspect taken into consideration is the adhering of the Candida albicans fibres, a bacterium frequently met at the oral cavity level of old patients, to different variations of acrylate, in search of ways of counter-attacking this tendency of a very resistant microbian structure.

Material And Methods: A number of 19 test-tubes were made under the shape of thin, rectangular plates, 40 mm long and 20 mm wide and a depth varying from 1.

Morphologic evaluation of radiotherapy in cervical carcinoma--a computerized morphometric approach.

Our work analyses the effects of radiotherapy in cervical carcinoma by computerized morphometry techniques that evaluate the morphologic changes in the specimens taken from pre and post-irradiation biopsies of 8 cases. These cases were diagnosed as squamous cell carcinoma, undifferentiated (1 case), moderately (5 cases) and well differentiated (2 cases). For each case, 40 relevant microscopic fields were chosen, reflecting the morphologic aspects before (20 fields) and after irradiation (20 fields).