A framework for assessing reliability of observer annotations of aerial wildlife imagery, with insights for deep learning applications.

There is growing interest in using deep learning models to automate wildlife detection in aerial imaging surveys to increase efficiency, but human-generated annotations remain necessary for model training. However, even skilled observers may diverge in interpreting aerial imagery of complex environments, which may result in downstream instability of models. In this study, we present a framework for assessing annotation reliability by calculating agreement metrics for individual observers against an aggregated set of annotations generated by clustering multiple observers' observations and selecting the mode classification.

Demystifying the functions of the mitochondrial ORFan proteins in bivalves with doubly uniparental inheritance.

Strict maternal inheritance of mitochondria is known to be the rule in animals, but over 100 species across six orders of bivalves possess doubly uniparental inheritance (DUI) of mitochondria. Under DUI, two distinctive sex-specific mitogenomes coexist. In marine and freshwater mussels, each mitogenome has an additional protein-coding gene, called female- and male-specific open reading frame or and , respectively.

Genomic ascertainment to quantify prevalence and cancer risk in adults with pathogenic and likely pathogenic germline variants in RASopathy genes.

Purpose: Genomic ascertainment of electronic health record-linked exome data in two large biobanks was used to quantify germline pathogenic/likely pathogenic (P/LP) variant prevalence, cancer prevalence, and survival in adults with non- RAS/mitogen-activated protein kinase genes (RASopathies).

Patients And Methods: Germline RASopathy variants were examined from adult participants in UK Biobank (UKBB; n=469,802), Geisinger MyCode (n=167,050) and Mount Sinai Bio (n=30,470). Variants were classified as per American College of Medical Genetics/Association for Molecular Pathology criteria and reviewed by a RASopathy variant expert.

First-in-human phase I trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein, SL-172154 in patients with platinum-resistant ovarian cancer.

Background: SL-172154 is a hexameric fusion protein adjoining the extracellular domain of SIRPα to the extracellular domain of CD40L via an inert IgG-derived Fc domain. In preclinical studies, a murine equivalent SIRPα-Fc-CD40L fusion protein provided superior antitumor immunity in comparison to CD47- and CD40-targeted antibodies. A first-in-human phase I trial of SL-172154 was conducted in patients with platinum-resistant ovarian cancer.

Identification, classification, and documentation of drug related problems in community pharmacy practice in Europe: a scoping review.

Background: Drug-related problems (DRPs) are significant issues in healthcare contributing to adverse health outcomes and increased healthcare costs. While community pharmacists play a pivotal role in identifying, classifying, and documenting DRPs, there is a need to map approaches undertaken.

Aim: The aim of this scoping review was to examine the approaches to identifying, classifying, and documenting DRPs in community pharmacies in Europe, and their associated barriers and facilitators.