Publications by authors named "D L Philippe"
Background: Emergency triage, which involves complex decision-making under stress and time constraints, may suffer from inaccuracies due to workplace distractions. A serious game was developed to simulate the triage process and environment. A pilot study was undertaken to collect preliminary data on the effects of distractors on emergency nurse triage accuracy.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate how often early cardiac CT finds stroke-related and non-stroke-related issues in patients suspected of having a stroke, and its impact on patient management.
- It analyzed data from 1,111 patients who had cardiac CT in addition to standard brain imaging protocols, identifying a higher prevalence of stroke-related conditions in those actually diagnosed with ischemic stroke.
- Results showed 8% had stroke-related findings and 15.6% had significant non-stroke findings, with some patients experiencing management changes due to these incidental discoveries.
Article Synopsis
- - Patients with multiple system atrophy (MSA) exhibit increased facial movements and muscle tone during sleep compared to those with Parkinson's disease and healthy controls, suggesting a phenomenon called sleep state dissociation.
- - A study analyzed facial muscle activity in 62 individuals (11 with MSA, 38 with Parkinson's, and 13 controls) using video-polysomnography, identifying specific facial movements like frowning and smiling, with "strained face" being notably prominent in MSA patients.
- - The findings indicate that MSA is associated with significant alterations in sleep muscle activity, potentially serving as a key indicator of the condition and its severity, especially during Non-Rapid Eye Movement (NREM) sleep.
In response to the EU cosmetics directive regulation and REACH legislation which encourage cell culture methods in order to reduce or replace the use of animals in toxicology studies, we settled the culture of prepubertal domestic cat seminiferous tubules in our validated BioAlter® model, usually used with prepubertal rat, called here BioAlter®-rat, by opposition to BioAlter®-cat settled here. We carried out a comparative study on the effects of 3 testicular toxicants, 1,3-dinitrobenzene at 60 μM, 2-methoxyacetic acid at 2.5 mM and carbendazim at 50 nM or 500 nM in both BioAlter®-cat and BioAlter®-rat over a 3-week culture period.
View Article and Find Full Text PDFVenous-thromboembolism (VTE) is increased in lung cancer patients (LCP) treated with immune-checkpoint inhibitors (ICIs) but risk factors are not identified and the Khorana Score (KS) is not validated. To assess VTE incidence and its clinical impact, to investigate potential clinical risk factors and KS performance in LCP. Retrospective analysis of LCP initiating ICIs treatment between June 2015 and November 2020 in a for-profit cancer center.
View Article and Find Full Text PDF