Publications by authors named "D L Osborne"

Continuously explored in pharmaceuticals, microemulsions and nanoemulsions offer drug delivery opportunities that are too significant to ignore, namely safe delivery of clinically relevant drug doses across biological membranes. Their effectiveness as drug vehicles in mucosal and (trans)dermal delivery is evident from the volume of published literature. Commonly, their ability to enhance skin permeation is attributed to dispersion size, a characteristic closely related to solubilization capacity.

View Article and Find Full Text PDF

Introgressive hybridization, the interbreeding and gene flow between different species, has become increasingly common in the Anthropocene, where human-induced ecological changes and the introduction of captively reared individuals are increasing secondary contact among closely related species, leading to gene flow between wild and domesticated lineages. As a result, domesticated-wild hybridization may potentially affect individual fitness, leading to maladaptive effects such as shifts in behavior or life-history decisions (e.g.

View Article and Find Full Text PDF

Although conspiracy belief may arise from a frustration of psychological needs, research has yet to investigate these relationships over time. Using four annual waves of longitudinal panel data in New Zealand (2019-2022; = 55,269), we examined the relationship between four psychological needs (namely belonging, control, meaning in life, and self-esteem) and conspiracy belief. Results from four random-intercept cross-lagged panel models reveal stable between-person effects indicating that those whose core needs are less satisfied tend to exhibit higher levels of conspiracy belief across time.

View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on understanding radiotracer extravasation in PET imaging, an area that hasn't been thoroughly examined but could improve clinical practices.
  • It aims to quantify the absorbed radiation doses from extravasation both at the injection site and its effects on nearby organs, while also exploring the biological effects at the cellular level.
  • Utilizing advanced simulations, including GATE and TOPAS-nBio, the researchers modeled a common PET scan scenario to calculate radiation doses and assess potential DNA damage from radiation exposure within affected cells.
View Article and Find Full Text PDF