Pressure Gradient as a Predictor of Time Needed to Drain Cerebrospinal Fluid Via an External Ventricular Drain.

Background: Consensus is lacking on best practices regarding treatment of elevated intracranial pressure. One method is placement of an external ventricular drain to divert cerebrospinal fluid via continuous or intermittent drainage.

Objective: To explore the time required for fluid to finish draining at various pressure gradients under high- and low-compliance conditions.

Adopting tomorrow's therapies today: a perspective review of adoptive cell therapy in lung cancer.

Lung cancer is the leading cause of all cancer-related deaths in the United States and remains a global health challenge. While targeted therapy has revolutionized the treatment landscape of nonsmall cell lung cancer, many patients lack actionable mutations. Immunotherapy, particularly immune checkpoint inhibitors (ICIs), have significantly impacted outcomes in lung cancer in the last decade.

Interleukin-1 Receptor Antagonists Partially Inhibited Histological Injury but Not Tissue Inflammation in a Sheep Model of Pregnancy.

Intrauterine inflammation is a significant cause of early preterm birth and fetal injury. There is a lack of effective interventions for intrauterine inflammation. This study aimed to determine whether direct fetal treatment with IL-1 receptor antagonists (IL-1RA), specifically anakinra (competitive IL-1RA) or rytvela (allosteric IL-1RA), could reduce intrauterine inflammation caused by intraamniotic injection of E.