Publications by authors named "D L Madden"
COVID-19 Vaccine Effectiveness and Barriers to Vaccination: Comparing Perceptions Based on Vaccination Status.
J Racial Ethn Health Disparities
December 2024
Article Synopsis
- * The NYCEAL conducted focus groups with NYC residents to assess their views on vaccine effectiveness and barriers to vaccination, categorizing participants by their vaccination status.
- * Key themes from the analysis included trust in science, perceived vaccine effectiveness, and how people's views evolved over time, suggesting that cognitive biases influenced perceptions but didn't always change vaccination behavior.
Koala ocular disease grades are defined by chlamydial load changes and increases in Th2 immune responses.
Front Cell Infect Microbiol
November 2024
Introduction: This study employs bulk RNA sequencing, PCR, and ELISA assays to analyze the pathological factors affecting the outcomes of ocular infections in koalas. It investigates the immune responses and gene expression profiles associated with various stages of koala ocular chlamydiosis.
Methods: A cohort of 114 koalas from Queensland, Australia were assessed, with 47% displaying clinical signs of ocular disease.
The African swine fever virus (ASFV) causes fatal disease in pigs and is currently spreading globally. Commercially safe vaccines are urgently required. Aiming to generate a novel live attenuated vaccine (LAV), a recombinant ASFV was generated by deleting the viral O174L (PolX) gene.
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- Pseudomonas aeruginosa causes respiratory infections in cystic fibrosis patients and produces a virulence factor called Cif, which worsens patient outcomes by decreasing CFTR levels and disrupting healing signals.!* -
- The virulence factor Cif is regulated by a protein called CifR, which is the first known bacterial transcriptional regulator that senses epoxides, although how it functions at a molecular level has not been fully explored.!* -
- Through biochemical and structural studies, researchers revealed how CifR binds to DNA and identified key changes in its structure that facilitate gene regulation, highlighting the critical role of the Cys107 residue in sensing epoxides and releasing DNA.!*
Invariant natural killer T (iNKT) cells are glycolipid-reactive T cells with potent immunoregulatory properties. iNKT cells activated with the marine-sponge-derived glycolipid, α-galactosylceramide (αGC), provide a universal source of T-cell help that has shown considerable promise for a wide array of therapeutic applications. This includes harnessing iNKT-cell-mediated immune responses to adjuvant whole inactivated influenza virus (WIV) vaccines.
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