Targeted degradation of oncogenic KRASG12V triggers antitumor immunity in lung cancer models.

KRAS is the most frequently mutated oncogene in lung adenocarcinoma, with G12C and G12V being the most predominant forms. Recent breakthroughs in KRASG12C inhibitors have transformed the clinical management of patients with G12C mutation and advanced our understanding of its function. However, little is known about the targeted disruption of KRASG12V, partly due to a lack of specific inhibitors.

The roles of cognitive dissonance and normative reasoning in attributions of minds to robots.

As a wide variety of intelligent technologies become part of everyday life, researchers have explored how people conceptualize agents that in some ways act and think like living things but are clearly machines. Much of this work draws upon the idea that people readily default to generalizing human-like properties to such agents, and only pare back on these generalizations with added thought. However, recent findings have also documented that people are sometimes initially hesitant to attribute minds to a machine but are more willing to do so with additional thought.

Predicting Exploration Crew Medical Officer Training Needs: Applying Evidence-Based Predictive Analytics to Space Medicine Training.

Introduction: Predictive analytics may be a useful adjunct to identify training needs for exploration class medical officers onboard deep space vehicles.

Methods: This study used a preliminary version of NASA's newest medical predictive analytics tool, the Medical Extensible Database Probabilistic Risk Assessment Tool (MEDPRAT), to test the application of predictive analytics to exploration crew medical officer curriculum design for 5 distinct design reference mission (DRM) profiles. Partial and fully treated paradigms were explored.

Metastatic Prostate Carcinoma to the Ankle Seen on Bone Scintigraphy and Extended Field-of-View PSMA PET/CT.

We describe a rare case of metastatic prostate carcinoma to the heel. Bone scintigraphy revealed high uptake simulating fractures. Standard PSMA PET/CT was negative.

Comparison of Camera-Acquired Vital Signs to Conventional Vital Signs in a Space-Analog Environment.

Introduction: Vital sign acquisition is a key component of modern medical care. In wilderness and space medical settings, vital sign acquisition can be a difficult process because of limitations on available personnel or lack of access to the patient. Camera-acquired vital signs could address each of these difficulties.