Publications by authors named "D L Kuh"
Background: Blood pressure, grip strength and lung function are frequently assessed in longitudinal population studies, but the measurement devices used differ between studies and within studies over time. We aimed to compare measurements ascertained from different commonly used devices.
Methods: We used a randomised cross-over study.
Objective: To investigate associations between age at natural menopause, particularly premature ovarian insufficiency (POI) (natural menopause before age 40 years), and incident type 2 diabetes (T2D) and identify any variations by ethnicity.
Research Design And Methods: We pooled individual-level data of 338,059 women from 13 cohort studies without T2D before menopause from six ethnic groups: White (n = 177,674), Chinese (n = 146,008), Japanese (n = 9,061), South/Southeast Asian (n = 2,228), Black (n = 1,838), and mixed/other (n = 1,250). Hazard ratios (HRs) of T2D associated with age at menopause were estimated in the overall sample and by ethnicity, with study as a random effect.
Article Synopsis
- This research investigates how genetic variations influence DNA methylation, which is crucial for understanding gene regulation and disease risk.
- The study analyzed DNA methylation across nearly 725,000 sites in blood samples from 2,358 individuals, finding that over a third of these sites are impacted by genetic variants called SNPs, mostly acting nearby.
- The findings enhance our understanding of DNA methylation mechanisms and can help prioritize genetic variants in further genetic studies; researchers have made their database available online for public use.*
Article Synopsis
- This study explored how infertility, miscarriage, and stillbirth are linked to the age at which women experience natural menopause, especially looking for differences between Asian and non-Asian women.
- Researchers analyzed data from 303,594 postmenopausal women, using statistical methods to account for factors like race, education, and health habits, to identify patterns in menopause timing.
- Results indicated that the median age at natural menopause was 50 years, with 2.1% of participants experiencing premature menopause and 8.4% having early menopause, but the specifics of the associations varied by race.
Introduction: The one-legged balance test is a common screening tool for fall risk. Yet, there is little empirical evidence assessing its prognostic ability. The study aims were to assess the prognostic accuracy of one-legged balance performance in predicting falls and identify optimal cut-points to classify those at greater risk.
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