Publications by authors named "D L Kaminsky"
Traversing the Diagnostic Dilemma: Leaving the Bronchodilator Response Behind.
J Allergy Clin Immunol Pract
July 2024
Background: The Phase III slope from a single breath nitrogen washout test provides information about ventilation heterogeneity (VH) in the lungs.
Purpose: To determine if the Phase III slope from the exhaled tracer gas concentration during a standard, single breath DCO test using rapid gas analysis provides similar information about VH.
Basic Procedures: Retrospective analysis of clinical pulmonary function laboratory data including spirometry, lung volumes, and DCO.
Background: Within-breath analysis of oscillometry parameters is a growing research area since it increases sensitivity and specificity to respiratory pathologies and conditions. However, reference equations for these parameters in White adults are lacking and devices using multiple sinusoids or pseudorandom forcing stimuli have been underrepresented in previous studies deriving reference equations. The current study aimed to establish reference ranges for oscillometry parameters, including also the within-breath ones in White adults using multi-sinusoidal oscillations.
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- The study investigates the impact of β-blocker prescriptions on COPD patients who experienced acute myocardial infarction (AMI), following concerns from the BLOCK-COPD trial where metoprolol was linked to increased hospitalizations.
- Conducted across 18 hospitals from June 2020 to May 2022, the research involved 579 COPD patients and aimed to evaluate the risks of mortality and adverse outcomes after starting β-blockers post-hospital discharge.
- Out of the COPD patients studied, 86.7% were prescribed β-blockers, leading to an analysis of their effects on overall health, including hospital stay lengths and respiratory events, over a six-month period.