Rationalization of the thermal properties of some polycyclic organophosphorus compounds by structural and QSPR analyses.

In this work, we establish quantitative structure-property relationships (QSPR) to predict the melting temperatures of diphosphine dioxides possessing a tetradecahydrophosphanthrene core, based on four two-parameter models. Three new compounds were synthesized using the Bouveault-Blanc reduction of appropriate tertiary phosphine oxides, and these compounds exhibit high melting temperatures (approximately 280-410 °C). Models were built using a dataset of 13 compounds, including the new ones.

The First Large Identification of 3ANX and NX Producing Isolates of in Manitoba, Western Canada.

Fusarium head blight, caused by , continues to be one of the most important and devastating fungal diseases on cereal grains including wheat, barley, and oat crops. produces toxic secondary metabolites that include trichothecene type A and type B mycotoxins. There are many variants of these toxins that are produced, and in the early 2010s, a novel type A trichothecene mycotoxin known as 3ANX (7-α hydroxy,15-deacetylcalonectrin) and its deacetylated product NX (7-α hydroxy, 3,15-dideacetylcalonectrin) were identified in Minnesota, USA.

Surface Chemistry Aspects of Ion Exchange in Basic Copper Salts.

Brochantite was precipitated using stoichiometric amounts of CuSO and NaOH and characterized by scanning electron microscopy, specific surface area, thermogravimetric analysis, and zeta potential. Brochantite can be converted into paratacamite, basic copper bromide, and copper phthalate by shaking the powder with solutions containing excess corresponding anions. By contrast, attempts to convert brochantite into basic iodide, acetate, nitrate, or rhodanide in a similar way failed, that is, the powder after shaking with solutions containing excess corresponding anions still showed the powder X-ray diffraction pattern of brochantite.

Efficient Gene-Editing in Human Pluripotent Stem Cells Through Simplified Assembly of Adeno-Associated Viral (AAV) Donor Templates.

Gene-edited human pluripotent stem cells provide attractive model systems to functionally interrogate the role of specific genetic variants in relevant cell types. However, the need to isolate and screen edited clones often remains a bottleneck, in particular when recombination rates are sub-optimal. Here, we present a protocol for flexible gene editing combining Cas9 ribonucleoprotein with donor templates delivered by adeno-associated virus (AAV) vectors to yield high rates of homologous recombination.