Publications by authors named "D L Kalpaxis"
Article Synopsis
- The study investigates how trace metals in seawater affect oxidative stress and protein synthesis in mussels.
- Mussels were exposed to copper, mercury, or cadmium over two different time periods, and oxidative damage was assessed through specific biomarkers.
- Results indicated that cadmium caused the most significant oxidative damage, though some effects diminished after prolonged exposure, suggesting potential applications in tracking marine pollution.
Background: The os trigonum (OT)-the most common accessory bone of the foot-although usually asymptomatic, may cause posterior ankle impingement syndrome (PAIS), which may be a severely debilitating problem for recreational or competitive athletes. The aim of the present study was to evaluate effectiveness of posterior ankle arthroscopy and to assess the outcome in the treatment of PAIS secondary to OT impingement or OT fractures within a group of young athletes and their return to previous sports level.
Methods: From 2011 to 2018, a retrospective review of 81 recreational athletes of mean age 27.
Over the last years, we have been focused on chloramphenicol conjugates that combine in their structure chloramphenicol base with natural polyamines, spermine, spermidine and putrescine, and their modifications. Conjugate , with spermidine (SPD) as a natural polyamine linked to chloramphenicol base, showed the best antibacterial and anticancer properties. Using as a prototype, we here explored the influence of the antibacterial and anticancer activity of additional benzyl groups on N1 amino moiety together with modifications of the alkyl length of the aminobutyl fragment of SPD.
View Article and Find Full Text PDFNumerous studies have shown the ability of trace metals to accumulate in marine organisms and cause oxidative stress that leads to perturbations in many important intracellular processes, including protein synthesis. This study is mainly focused on the exploration of structural changes, like base modifications, scissions, and conformational changes, caused in 18S and 5S ribosomal RNA (rRNA) isolated from the mussel Mytilus galloprovincialis exposed to 40μg/L Cu, 30μg/L Hg, or 100μg/L Cd, for 5 or 15days. 18S rRNA and 5S rRNA are components of the small and large ribosomal subunit, respectively, found in complex with ribosomal proteins, translation factors and other auxiliary components (metal ions, toxins etc).
View Article and Find Full Text PDFArticle Synopsis
- Chloramphenicol (CAM) is a bacteriostatic antibiotic that inhibits bacterial protein synthesis and has specific effectiveness against bacteria causing meningitis.
- While it has some bactericidal properties, resistance and side effects like neurotoxicity and hematologic disorders limit its use in clinical settings.
- The review discusses past and current efforts to develop CAM derivatives with better pharmacological properties and their potential roles in studying the ribosomal catalytic center.