Minimalist Natural ORPphilin Macarangin B Delineates OSBP Biological Function.

OSBP ligands from the ORPphilin family are chemically complex natural products with promising anticancer properties. Here, we describe macarangin B, a natural racemic flavonoid selective for OSBP, which stands out from other ORPphilins due to its structural simplicity and distinct biological activity. Using a bioinspired strategy, we synthesized both (,,) and (,,)-macarangin B enantiomers, enabling us to study their interaction with OSBP based on their unique optical properties.

Investigating land cover changes and their impact on land surface temperature in Tay Ninh province, Vietnam.

Land surface temperature (LST) serves as a crucial indicator for evaluating the effects of different environmental factors on the ecosystem, including alterations in land use, climate variations, and emissions of greenhouse gases. This comprehensive study used remote sensing data to analyze changes and effects of land use/land cover (LULC) on LST in Tay Ninh province, Vietnam, from 1988-2023. Landsat satellite images in 1988, 2004, and 2023 were preprocessed and supervised classification on ArcGIS 10.

Never tested for HIV among men who have sex with men, Hanoi, Vietnam: correlates and missed opportunities.

Introduction: Understanding levels of HIV testing among populations at risk for acquisition is essential to meeting the goal of the United Nations that 95% of individuals living with HIV know their status. This study assessed HIV testing prevalence among men who had sex with men (MSM), characteristics of MSM who have never tested for HIV, and missed testing opportunities in Hanoi, Vietnam.Methods: We measured the prevalence of never testing for HIV and missed opportunities for testing in the baseline data of a cohort study of MSM recruited in 2017-2019 in Hanoi.

Modulation of gill surface area does not correlate with oxygen loss in .

Air-breathing fish risk losing aerially sourced oxygen to ambient hypoxic water since oxygenated blood from the air-breathing organ returns through the heart to the branchial basket before distribution. This loss is thought to help drive the evolutionary reduction in gill size with the advent of air-breathing. In many teleost fish, gill size is known to be highly plastic by modulation of their anatomic diffusion factor (ADF) with inter-lamellar cell mass (ILCM).

Disclosure of HIV Status in Healthcare Settings: Practices and Considerations among Women Living with HIV/AIDS in Vietnam.

Objective: This study investigated women living with HIV/AIDS (WLHA)'s practices and decision-making regarding disclosure of HIV status in healthcare settings in Vietnam. Disclosure of HIV status in healthcare settings is under-studied.

Methods: We conducted in-depth interviews with 30 WLHA in Hanoi, Vietnam.