Association between visceral adipose surrogates and infertility among reproductive-aged females: a cross-sectional study.

Background: Visceral adipose tissue (VAT) exerts a substantial influence on female infertility. Nevertheless, the relationship between VAT surrogates and female infertility remains ambiguous.

Methods: This study employed a cross-sectional design and analyzed data from the National Health and Nutrition Examination Survey (NHANES, 2012-2016).

Incremental Value of Pericoronary Adipose Tissue Radiomics Models in Identifying Vulnerable Plaques.

Objective: Inflammatory characteristics in pericoronary adipose tissue (PCAT) may enhance the diagnostic capability of radiomics techniques for identifying vulnerable plaques. This study aimed to evaluate the incremental value of PCAT radiomics scores in identifying vulnerable plaques defined by intravascular ultrasound imaging (IVUS).

Methods: In this retrospective study, a PCAT radiomics model was established and validated using IVUS as the reference standard.

Non-canonical signaling initiated by hormone-responsive G protein-coupled receptors from subcellular compartments.

G protein-coupled receptors (GPCRs), the largest family of membrane receptors in the mammalian genomes, regulate almost all known physiological processes by transducing numerous extracellular stimuli including almost two-thirds of endogenous hormones and neurotransmitters. The traditional view held that GPCR signaling occurs exclusively at the cell surface, where the receptors bind with the ligands and undergo conformational changes to recruit and activate heterotrimeric G proteins. However, with the application of advanced biochemical and biophysical techniques, this conventional model is challenged by the elucidation of spatiotemporal GPCR activation with the evidence that receptors can signal from subcellular compartments to exhibit various molecular and cellular responses with physiological and pathophysiological relevance.

Interaction between Vitamin D homeostasis, gut microbiota, and central precocious puberty.

Central precocious puberty (CPP) is an endocrine disease in children, characterized by rapid genital development and secondary sexual characteristics before the age of eight in girls and nine in boys. The premature activation of the hypothalamic-pituitary-gonadal axis (HPGA) limits the height of patients in adulthood and is associated with a higher risk of breast cancer. How to prevent and improve the prognosis of CPP is an important problem.