Publications by authors named "D L Fouts"
Article Synopsis
- There is a significant lack of understanding regarding how certain Gram-negative bacteria, particularly from the Enterobacterales order, cause severe blood infections (bacteremia) despite their survival strategies being more suited for different environments.
- Enterobacterales species, such as E. coli and Klebsiella pneumoniae, are prevalent in bacteremia cases, often leading to life-threatening conditions like sepsis due to immune system responses.
- Researchers identified 18 key genes linked to the bacteria's survival and tested their effects using mutant strains in a mouse model, discovering several genes whose mutations weakened the bacteria, paving the way for potential new treatments for bloodstream infections.
The innate immune system eliminates bloodstream pathogens such as Escherichia coli in part through complement protein deposition and subsequent bacterial death (i.e., "serum killing").
View Article and Find Full Text PDFThe fungal microbiota plays an important role in the pathogenesis of alcohol-associated liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD). In this study, we aimed to compare changes of the fecal fungal microbiota between patients with ALD and NAFLD and to elucidate patterns in different disease stages between the two conditions. We analyzed fungal internal transcribed spacer 2 (ITS2) sequencing using fecal samples from a cohort of 48 patients with ALD, 78 patients with NAFLD, and 34 controls.
View Article and Find Full Text PDFBackground: Colistin is one of the last resort therapeutic options for treating carbapenemase-producing Enterobacterales, which are resistant to a broad range of beta-lactam antibiotics. However, the increased use of colistin in clinical and livestock farming settings in Thailand and China, has led to the inevitable emergence of colistin resistance. To better understand the rise of colistin-resistant strains in each of these settings, we characterized colistin-resistant Enterobacterales isolated from farmers, swine, and hospitalized patients in Thailand.
View Article and Find Full Text PDFEscherichia coli sequence type 131 (ST131) is a globally dominant multidrug-resistant clone, although its clinical impact on patients with bloodstream infection (BSI) is incompletely understood. This study aims to further define the risk factors, clinical outcomes, and bacterial genetics associated with ST131 BSI. A prospectively enrolled cohort study of adult inpatients with E.
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