Antimicrob Steward Healthc Epidemiol
December 2024
Objective: Examine the relationship between patients' race and prescriber antibiotic choice while accounting for differences in underlying illness and infection severity.
Design: Retrospective cohort analysis.
Setting: Acute care facilities within an academic healthcare system.
Introduction: The aggregation and spread of hyperphosphorylated, pathological tau in the human brain is hypothesized to play a key role in Alzheimer's disease (AD) as well as other neurogenerative tauopathies. O-GlcNAcylation, an important post-translational modification of tau and many other proteins, is significantly decreased in brain tissue of AD patients relative to healthy controls. Increased tau O-GlcNAcylation has been shown to reduce tau pathology in mouse in vivo tauopathy models.
View Article and Find Full Text PDFObjectives: The placenta accreta spectrum disorders (PASD) are associated with significant maternal and neonatal morbidity and mortality worldwide. As cesarean delivery rates increase, so does the rate of PASD. PASD antepartum diagnosis and perioperative management are evolving, and we primarily aimed to share our tertiary care centre's institutional approach and outcomes over a decade.
View Article and Find Full Text PDFPlate tectonics is a unique feature of Earth, but its proposed time of initiation is still controversial, with published estimates ranging from ca. 4.2 to 0.
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