Publications by authors named "D L Croteau"
Introduction: During aging, many cellular processes, such as autophagic clearance, DNA repair, mitochondrial health, metabolism, nicotinamide adenine dinucleotide (NAD+) levels, and immunological responses, become compromised. Urolithin A (UA) and Nicotinamide Riboside (NR) are two naturally occurring compounds known for their anti-inflammatory and mitochondrial protective properties, yet the effects of these natural substances on microglia cells have not been thoroughly investigated. As both UA and NR are considered safe dietary supplements, it is equally important to understand their function in normal cells and in disease states.
View Article and Find Full Text PDFBackground: Risk factors for progressive multifocal leukoencephalopathy (PML) associated with sphingosine-1-phosphate receptor (S1PR) modulators are not as well-characterized as for natalizumab. We characterized S1PR modulator-associated PML cases and risk factors for PML using spontaneous adverse event reports.
Methods: We reviewed case reports from the FDA Adverse Event Reporting System database and the medical literature.
Article Synopsis
- * The study investigated NR's effects using various models that simulate oxidative stress, aging, and AD, focusing on neuronal survival and the complex interactions of reactive species.
- * Findings reveal that NR treatment affects specific protein networks related to energy metabolism and neurotransmitter regulation, suggesting potential pathways for modifying the disease processes in AD.
Article Synopsis
- Alzheimer's disease (AD) is a severe neurodegenerative disorder characterized by the buildup of amyloid plaques and tau tangles, leading to memory loss and brain damage.
- Researchers used a C. elegans model to explore the role of DNA glycosylases in AD progression, discovering that certain genetic modifications improved mitochondrial health, lifespan, and cognitive function in nematodes with tau pathology.
- The study highlights the importance of the DNA glycosylase NTH-1, showing it has additional functions beyond its enzyme activity, suggesting it could be a potential target for therapeutic strategies against tau-related diseases.
Women's Experiences of Mechanical Balloon Catheter Induction With Self-Traction.
J Obstet Gynecol Neonatal Nurs
September 2024
Objective: To explore women's experiences of mechanical labor induction using a balloon catheter with self-traction.
Design: Descriptive qualitative.
Setting: Birth unit of an urban hospital in Quebec, Canada.