Publications by authors named "D L Cousminer"
Article Synopsis
- Scientists looked at the timing of when girls start their periods (called menarche) and how it can affect their health later in life.
- They studied about 800,000 women and found over a thousand genetic signals that influence when menstruation starts.
- Some women have a much higher chance of starting their periods too early or too late based on their genetic makeup, suggesting that genes play a big role in this process!
Background: Drug targets with genetic evidence are expected to increase clinical success by at least twofold. Yet, translating disease-associated genetic variants into functional knowledge remains a fundamental challenge of drug discovery. A key issue is that the vast majority of complex disease associations cannot be cleanly mapped to a gene.
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- - This study explores how growth patterns during puberty relate to future health outcomes by analyzing height data from about 56,000 individuals across various ancestries using a technique called SITAR.
- - The researchers identified 26 significant genetic loci linked to height growth during puberty and found that different growth rates are associated with various health risks, like type 2 diabetes and heart conditions.
- - The findings suggest that there are multiple growth trajectories during puberty, each influencing adult health differently, indicating that no single growth pattern is the "best" for lifelong health outcomes.