Publications by authors named "D L Bratton"
Article Synopsis
- Chronic Granulomatous Disease (CGD) is characterized by sterile pyogranulomas and increased cytokine production, indicating hyperinflammation.
- Research using zymosan-treated CGD and wild-type mice revealed that CGD cells form aggregates of neutrophils and monocyte-derived macrophages (MoMacs), driven by LTB signaling and CD11b expression.
- Disruption of CD11b in CGD mice led to poorly organized pyogranulomas and decreased inflammatory cytokine production, highlighting the importance of neutrophil aggregation in the inflammatory response.
Introduction: Loss of NADPH oxidase activity results in proinflammatory macrophages that contribute to hyperinflammation in Chronic Granulomatous Disease (CGD). Previously, it was shown in a zymosan-induced peritonitis model that gp91 (CGD) monocyte-derived macrophages (MoMacs) fail to phenotypically mature into pro-resolving MoMacs characteristic of wild type (WT) but retain the ability to do so when placed in the WT milieu. Accordingly, it was hypothesized that soluble factor(s) in the CGD milieu thwart appropriate programming.
View Article and Find Full Text PDFObjective: To date, no patient-reported outcome measures have been specifically developed to assess pharmacological treatment effect in participants with severe chronic rhinosinusitis (CRS) with recurrent bilateral nasal polyps (NP). These studies aimed to assess (1) the psychometric properties and (2) content validity of Visual Analogue Scales (VAS) assessing NP symptom severity.
Study Design: (1) Retrospective psychometric validation study using clinical trial data and (2) cross-sectional qualitative patient interview study.