Publications by authors named "D L Bliwise"
Article Synopsis
- Nocturia (waking up at night to urinate) and chronic insomnia often affect older adults together, leading to more severe sleep disturbances, yet treatments usually focus on one issue at a time.
- A study involved older adults with both conditions to test a new treatment approach combining cognitive-behavioral therapy for insomnia and nocturia, as well as a control health education program.
- Results showed that participants in the combined treatment group experienced a greater reduction in the number of nightly nocturia episodes compared to those in the control group over four months, suggesting the method's feasibility for future research.
Article Synopsis
- The study aimed to compare the effectiveness of modafinil versus amphetamine-dextroamphetamine in treating narcolepsy type 2 and idiopathic hypersomnia through a randomized, blinded trial involving 44 adults over 12 weeks.
- Results showed that while modafinil improved sleepiness levels (5.0 points on the Epworth scale) more than amphetamine-dextroamphetamine (4.4 points), the latter was noninferior in several secondary measures of symptoms and disease severity.
- Adverse effects were more prevalent with modafinil, including higher rates of anxiety, while amphetamine-dextroamphetamine showed less dropouts due to adverse events, suggesting implications for treatment choices in these disorders.
IGLON5 Frequency in Idiopathic REM Sleep Behavior Disorder: A Multicenter Study.
Neurol Neuroimmunol Neuroinflamm
November 2024
Background And Objectives: Idiopathic/isolated REM sleep behavior disorder (iRBD) has been strongly linked to neurodegenerative synucleinopathies such as Parkinson disease, dementia with Lewy bodies, and multiple system atrophy. However, there have been increasing reports of RBD as a presenting feature of serious and treatable autoimmune syndromes, particularly IGLON5. This study's objective was to investigate the frequency of autoantibodies in a large cohort of participants with iRBD.
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- Obstructive sleep apnea (OSA) is prevalent among older adults, particularly those over 65, and its relationship with posttraumatic stress disorder (PTSD) requires further research for personalized treatment approaches.
- The study utilized a cross-sectional design involving male Vietnam War veteran twins to examine the link between PTSD symptoms and OSA, employing in-laboratory polysomnography for evaluation.
- Results indicated that a 15-point increase in PTSD symptom severity was correlated with a higher apnea-hypopnea index, suggesting that PTSD may significantly impact OSA severity.