Publications by authors named "D L Auci"
Background: All-trans retinoic acid (ATRA) is a biologically active isomer of retinoic acid (RA). Topical ATRA (retin-a, retin-a micro, atralin, renova, and avita) is the active pharmaceutical ingredient for FDA-approved treatments for acne and skin wrinkles. Oral formulations (Vesanoid) treat acute promyelocytic leukemia, but oral dosing can induce severe side effects.
View Article and Find Full Text PDFOral encapsulated transforming growth factor β1 reduces endogenous levels: Effect on inflammatory bowel disease.
World J Gastrointest Pharmacol Ther
November 2020
Article Synopsis
- TreXTAM is an oral treatment combining TGFβ and ATRA aimed at combating inflammatory bowel disease (IBD) by targeting the gut's immune structures.
- In animal studies, TreXTAM significantly reduced TGFβ levels in the colon by about 50%, indicating a local feedback mechanism, but did not affect levels in the small intestine or lymph nodes.
- The research suggests that while TreXTAM lowers TGFβ in the gut and bloodstream, its clinical application may be beneficial for IBD and conditions involving excessive TGFβ signaling, despite some limitations observed with single-agent TGFβ treatment in IBD models.
Type 1 diabetes (T1D) is a multifactorial autoimmune disease that develops as a consequence of macrophage- and T cell-dependent pancreatic β-cell death. Multiple approaches for induction of anti-inflammatory/regulatory mechanisms that would attenuate T1D have been utilized, with little or no beneficial effects. To achieve prolonged stimulation of regulatory immune cells, we orally introduced microparticles (MPs) loaded with all-trans retinoic acid (ATRA) and transforming growth factor-β (TGF-β) to C57BL/6 mice treated with multiple low doses of streptozotocin (MLDS) for T1D induction.
View Article and Find Full Text PDFAnti-Fibrotic Potential of All Trans Retinoic Acid in Inflammatory Bowel Disease.
J Gastroenterol Pancreatol Liver Disord
May 2018
Synergy of Transforming Growth Factor Beta 1 and All Trans Retinoic Acid in the Treatment of Inflammatory Bowel Disease: Role of Regulatory T cells.
J Gastroenterol Pancreatol Liver Disord
August 2016