Publications by authors named "D Krull"
Article Synopsis
- - The discovery of biomarkers for drug development is constrained by limited tissue samples from core needle biopsies, which can hinder the analysis of tissue heterogeneity and cell interactions due to standard 'omics platforms consuming large amounts of tissue.
- - Current spatial transcriptomics technologies have low throughput and limited transcriptome coverage, while the Digital Spatial Profiling (DSP) method allows for scalable analysis of the entire transcriptome and high-plex protein analysis from a single tissue slide.
- - The DSP Scientific Consortium has established best practices to enhance the use of spatial biology tools in drug discovery, aiming to optimize tissue analysis across various research fields to better understand disease biology and discover potential therapeutic targets.
Article Synopsis
- Advances in AI and machine learning have enhanced the automation of digital image analysis, improving the identification of tissue sub-compartments and cellular phenotypes, especially in clinical and research scenarios.
- The study focuses on identifying immune cell markers, specifically CD3/LAG3 T-cells, in colorectal tissue, which is important for understanding treatment targets for autoimmune diseases.
- A new semi-automated imaging and analysis pipeline combines brightfield and fluorescence imaging techniques to effectively segment tissue and identify cellular phenotypes, demonstrating its effectiveness in revealing LAG3 T-cells in ulcerative colitis biopsies.
Previous research suggests that people, especially religious people, are more opposed to active euthanasia, such as a lethal injection, than to passive euthanasia, such as withdrawing life support. The current research proposes a possible explanation for this finding-that active euthanasia is viewed as interfering with the natural course of life and death, but passive euthanasia is viewed as allowing it to take place. Two studies yielded results consistent with this hypothesis and found that how people think about the natural course of life and death substantially explained the greater opposition to active euthanasia among more religious people.
View Article and Find Full Text PDFReligiosity often predicts better adjustment after the death of a loved one, but findings vary. One source of variability could be the perceived faithfulness of the deceased. In study 1, more religious college students found the death of a hypothetical faithful person to be less sad than the death of a hypothetical unfaithful person, whereas less religious college students did not.
View Article and Find Full Text PDFIntroduction: Delayed graft function (DGF) following renal transplantation is a manifestation of acute kidney injury (AKI) leading to poor long-term outcome. Current treatments have limited effectiveness in preventing DGF. Interleukin-18 (IL18), a biomarker of AKI, induces interferon-γ expression and immune activation.
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