Publications by authors named "D Krizsan-Agbas"
Article Synopsis
- - The study aimed to find out if spike-triggered intraspinal microstimulation (ISMS) helps improve motor skills in rats with spinal cord injuries by using activity-dependent stimulation (ADS).
- - Adult male rats with spinal cord injuries were divided into two groups: one receiving ADS therapy and one serving as a control; therapy sessions involved stimulation in the spinal cord based on brain activity from the hindlimb motor cortex.
- - Results showed that ADS therapy rats had significantly better locomotor performance and fewer foot faults compared to control and pre-therapy conditions, indicating that chronic stimulation can boost recovery in motor functions post-injury.
Background: Closed-loop neuromodulation systems have received increased attention in recent years as potential therapeutic approaches for treating neurological injury and disease.
Objective: The purpose of this study was to assess the ability of intraspinal microstimulation (ISMS), triggered by action potentials (spikes) recorded in motor cortex, to alter synaptic efficacy in descending motor pathways in an anesthetized rat model of spinal cord injury (SCI).
Methods: Experiments were carried out in adult, male, Sprague Dawley rats with a moderate contusion injury at T8.
The purpose of this study was to determine the effects of spinal cord injury (SCI) on spike activity evoked in the hindlimb spinal cord of the rat from cortical electrical stimulation.Adult, male, Sprague Dawley rats were randomly assigned to a Healthy or SCI group. SCI rats were given a 175 kDyn dorsal midline contusion injury at the level of the T8 vertebrae.
View Article and Find Full Text PDFChildren with Rett syndrome show abnormal cutaneous sensitivity. The precise nature of sensory abnormalities and underlying molecular mechanisms remain largely unknown. Rats with methyl-CpG binding protein 2 (MeCP2) mutation, characteristic of Rett syndrome, show hypersensitivity to pressure and cold, but hyposensitivity to heat.
View Article and Find Full Text PDFThe purpose of this study was to examine neuronal activity levels in the hindlimb area of motor cortex following spinal cord injury (SCI) in rats and compare the results with measurements in normal rats. Fifteen male Fischer-344 rats received a 200 Kdyn contusion injury in the thoracic cord at level T9-T10. After a minimum of 4 weeks following SCI, intracortical microstimulation (ICMS) and single-unit recording techniques were used in both the forelimb and hindlimb motor areas (FLA, HLA) under ketamine anesthesia.
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