Publications by authors named "D Kristt"
Nitric Oxide (NO) and its precursor l-arginine were found to inhibit feeding in rats with a low motivation to eat, as they do in Aplysia. In rats that are relatively satiated, treatment with an NO blocker increased feeding, and treatment with an NO donor or with either of 2 doses of l-arginine inhibited feeding. NO and l-arginine modulated several parameters of feeding, such as the total duration of appetitive behaviors, the time spent feeding, the quantity of food eaten and the number of feeding bouts.
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- Alzheimer's disease (AD) is marked by cognitive decline and the accumulation of amyloid-β plaques and neurofibrillary tangles, with inflammation playing a significant role in its development.
- A study found that the expression of CD44 and its splice variants, particularly CD44V10, was significantly higher in AD patients, with specific localization to plaques and neurons.
- Inhibiting CD44V10 showed protective effects against Aβ-induced toxicity in neuronal cells, suggesting that targeting this variant could be a potential new treatment strategy for Alzheimer's disease.
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- Previous studies suggest a link between MHC and mating preferences, but it's still unclear if individuals with similar HLA determinants prefer to mate. The study focuses on the unique genetic and cultural context of the contemporary Israeli population and its impact on mate selection.
- The study assessed 1,002 unmarried couples, 308 married couples, and a control group of fictitious couples, evaluating their HLA and short-tandem-repeat (STR) genetic markers for shared traits.
- Results showed that actual sex partners shared HLA determinants more frequently than those in the control group, indicating a possible preference in mate selection, but STR markers did not indicate any genetic background similarity, challenging assumptions about mating and genetic diversity.
Autism Spectrum Disorders (ASD) are a group of heterogeneous neurodevelopmental conditions presenting in early childhood with a prevalence ranging from 0.7% to 2.64%.
View Article and Find Full Text PDFAlthough cytological screening for cervical neoplasia has lowered mortality rates, current screening methods are plagued by sub-optimal sensitivity and/or specificity. The purpose of this study was to compare the performance of the new CellDetect® staining technology as a potential screening tool. This initial, non-blinded study, utilized samples are taken at a community-based clinic.
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