Fatty Acid Synthase-Derived Lipid Stores Support Breast Cancer Metastasis.

Lipid accumulation is associated with breast cancer metastasis. However, the mechanisms underlying how breast cancer cells increase lipid stores and their functional role in disease progression remain incompletely understood. Herein we quantified changes in lipid metabolism and characterized cytoplasmic lipid droplets in metastatic versus non-metastatic breast cancer cells.

Intraosseous Mucoepidermoid Carcinoma in the Mandible: A Report of Two Cases and Literature Review.

Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of salivary glands.It usually occurs in major salivary glands. The occurrence of intraosseous MEC (IMEC) is rare and is usually seen in the mandibular premolar and molar regions.

Navigating health policies and programs in India: exploring opportunities to improve rare disease management and orphan drug research.

Background: Rare disease (RD) management and orphan drug development in India face various hurdles regarding the implementation and adoption of comprehensive policies, lack of dedicated regulatory frameworks, and absence of epidemiological data. Current rare disease policy focuses more on strengthening the diagnostics and lacks a proper comprehensive treatment framework to ensure favorable clinical outcomes. Indian patients are largely excluded from global orphan drug clinical trials.

Comparing Different Pathways in Medical Education and Surgical Training: A Global Survey of Surgeons.

Background: Currently, interest in surgical careers is declining globally, whereas aging populations are contributing to a rising demand for surgical procedures. Surgeons who conduct scientific investigations and share clinical advances internationally pay little attention to comparing differences in ways nations attract, educate, and train their surgeons. This study compares international pathways toward surgeon development with the aim of seeking best practices and improving the outlook of surgery as an attractive career.