Publications by authors named "D Krieger"
Neurons become more vulnerable to stress factors with age, which leads to increased oxidative DNA damage, decreased activity of mitochondria and lysosomes, increased levels of p16, decreased LaminB1 proteins, and the depletion of the dendritic tree. These changes are exacerbated in vulnerable neuronal populations during the development of neurodegenerative diseases. Glu-Asp-Arg (EDR) and Lys-Glu-Asp (KED), and Ala-Glu-Asp-Gly (AEDG) peptides have previously demonstrated neuroprotective effects in various models of Alzheimer's disease.
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- A 55-year-old woman with low TSH and thyroid nodules was evaluated for neck pain and difficulty swallowing, leading to a fine needle aspiration that suggested potential malignancy.* -
- After diagnosis of subacute thyroiditis, characterized by elevated ESR and specific symptoms, she underwent a right lobectomy due to initial concerns for cancer.* -
- Ultimately, her thyroid function and inflammation returned to normal within seven months, emphasizing the need to differentiate between subacute thyroiditis and cancer to prevent misdiagnosis.*
Purpose: Subclinical thyroid dysfunction is a marker for atrial fibrillation (AF) and stroke risk. This study explored the effects of AF screening according to thyroid-stimulating hormone (TSH) levels.
Methods: An AF screening trial (the LOOP study) was analyzed post-hoc according to baseline TSH.
Background: Left atrial (LA) speckle tracking provides detailed information on atrial function. Its utility for predicting subclinical atrial fibrillation (SCAF) is unclear. Therefore, we sought to investigate whether LA strain measures could predict SCAF detected by long-term continuous rhythm monitoring.
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- * The LOOP study involved 6,004 AF-naïve individuals aged 70-90 with stroke risk factors, comparing outcomes of those monitored with an implantable loop recorder to usual care, finding that a higher ABC-stroke score significantly indicated increased stroke risk.
- * However, results showed that the ABC-stroke score did not effectively identify which individuals would benefit from AF screening or preventive treatment, suggesting the need for further investigation into its clinical utility.