The distribution of pemphigus vulgaris-IgG subclasses and their reactivity with desmoglein 3 and 1 in pemphigus patients and their first-degree relatives.

Background: Pemphigus vulgaris (PV) autoantibodies (PV-IgG) have been found in 40-70% of sera of first-degree relatives of pemphigus patients.

Objectives: To determine the possible role of PV-IgG subclasses in the pathogenesis of the disease.

Patients And Methods: Study groups comprised 25 PV patients, 55 unaffected family members and 56 sera of healthy individuals.