The use of Baypamun N in crowding associated infectious respiratory disease: efficacy of Baypamun N (freeze dried product) in 4-10 month old horses.

The efficacy of an immunomodulator, Baypamun N, was tested in 4-10-month-old horses which were exposed to stress by weaning, transport and commingling with yearlings from different breeders (crowding). Verum (n = 26) and placebo animals (n = 27) received three intramuscular injections of the investigational preparations (days 0, 2, 9) starting at the day of commingling in one stable. The incidence of acute respiratory disease was high during the first 4 weeks after commingling.

The use of Baypamun N in crowding-associated infectious respiratory disease: efficacy of Baypamun N (freeze dried product) in 2-week-old veal calves.

The efficacy of an immunomodulator, Baypamun N, was tested in 10-20-day-old veal calves from different farms, which were exposed to stress by transport and commingling (crowding). Verum and placebo animals (n = 50, each group) received three intramuscular injections of the investigational products (days 0, 2, 4) starting the day of arrival on the farm. Data from 49 calves in each group could be used for statistical evaluation.

A gE deleted infectious bovine rhinotracheitis marker vaccine for use in improved bovine herpesvirus 1 control programs.

Based on a glycoprotein E (gE) deleted bovine herpesvirus 1 (BHV1) strain (Kaashoek et al., 1994) a killed virus as well as a modified live virus marker vaccine have been developed that allow differentiation between immunized and BHV1 infected cattle. Safety and efficacy of both vaccines were tested extensively following the current European Union (EU) requirements for the development of bovine vaccines.

Safety aspects in the development of an infectious bovine rhinotracheitis marker vaccine.

Clinical trials in cattle demonstrated that the IBR marker modified live vaccine based on the gE-deleted IBR strain Difivac is immunogenic and safe for bovines of all ages. Potential effects of the vaccine virus have also been tested in swine and sheep and proved safe for these species as well. For evaluation of other environmental aspects, the spread of the vaccine virus after immunisation was investigated.

[The effectiveness of the paramunity inducer Baypamun (PIND-ORF) for the prevention and metaphylaxis of an experimental infection with the infectious bovine rhinotracheitis virus in cattle].

Efficacy of the paramunity inducer Baypamun (PIND-ORF) was evaluated by an IBR challenge trial in cattle, as one model for infectious diseases in bovine. Prophylactic treatment with Baypamun protected cattle against manifestation of clinical symptoms after experimental IBR infection. The degree of protection depended on the time between paramunization and challenge infection.