Publications by authors named "D Kraemmer"
Article Synopsis
- Human saliva contains extracellular vesicles (EVs) that can activate blood coagulation through the presence of extrinsic tenase complexes, which include tissue factor and activated factor VII.
- Individuals with severe hemophilia A, who lack FVIII, have salivary EVs that can compensate for their condition by generating FXa, leading to infrequent oropharyngeal bleeding.
- In contrast, people with severe FVII deficiency lack these functional extrinsic tenase complexes in their saliva, resulting in more frequent oropharyngeal bleedings; however, adding recombinant FVIIa can restore coagulation potential in their saliva.
: Postpartum haemorrhage (PPH) is a frequent complication of childbirth that is difficult to predict. Predelivery coagulation biomarkers may help to guide preventive strategies. Our objective was to evaluate the association of predelivery haemostatic biomarkers with non-severe PPH.
View Article and Find Full Text PDFFunctional limitations 3 and 12 months after venous thromboembolism: a cohort study.
Res Pract Thromb Haemost
May 2024
Article Synopsis
- Venous thromboembolism (VTE) can lead to long-term complications, prompting a study to evaluate the relationship between initial clinical characteristics at diagnosis and functional limitations at 3 and 12 months post-diagnosis.
- The study involved 307 patients (mostly middle-aged), where assessments showed improvements in functional status over time, but scores remained below pre-VTE levels.
- Female sex, higher body mass index, older age, and pre-existing health conditions were identified as significant factors predicting ongoing functional limitations after VTE.
Background: In patients with mild-to-moderate bleeding disorders (MBD), von Willebrand disease (VWD) is diagnosed at von Willebrand factor (VWF) levels ≤50 IU/dL. Although VWF levels are unstable, repeated testing for VWD diagnosis is not necessarily advised in recent guidelines.
Objectives: To analyze the relevance of repeated VWF testing to diagnose VWD in patients with MBD.
Background: With population pharmacokinetic (PK) modeling more readily available and PK-guided prophylaxis endorsed by current hemophilia guidelines, we conducted a systematic review to summarize current evidence in the literature.
Objectives: To assess the efficacy of PK-guided compared with non-PK-guided prophylaxis.
Methods: We did not restrict inclusion to specific study design labels and included all studies consisting of at least one distinct cohort arm receiving PK-guided prophylaxis.