Characterization of the First Secreted Sorting Nexin Identified in the Protists.

Proteins of the sorting nexin (SNX) family present a modular structural architecture with a phox homology (PX) phosphoinositide (PI)-binding domain and additional PX structural domains, conferring to them a wide variety of vital eukaryotic cell's functions, from signal transduction to membrane deformation and cargo binding. Although SNXs are well studied in human and yeasts, they are poorly investigated in protists. Herein, is presented the characterization of the first SNX identified in protozoan parasites encoded by the BPK_352470 gene.

Magnetic skyrmions in FePt nanoparticles having Reuleaux 3D geometry: a micromagnetic simulation study.

The magnetization reversal in magnetic FePt nanoelements having Reuleaux 3D geometry is studied using micromagnetic simulations employing Finite Element discretizations. Magnetic skyrmions are revealed in different systems generated by the variation of the magnitude of the magnetocrystalline anisotropy which was kept normal to the nanoelement's base and parallel to the applied external field. The topological quantity of skyrmion number is computed in order to characterize micromagnetic configurations exhibiting skyrmionic formations.

Needles: Toward Large-Scale Genomic Prediction with Marker-by-Environment Interaction.

Genomic prediction relies on genotypic marker information to predict the agronomic performance of future hybrid breeds based on trial records. Because the effect of markers may vary substantially under the influence of different environmental conditions, marker-by-environment interaction effects have to be taken into account. However, this may lead to a dramatic increase in the computational resources needed for analyzing large-scale trial data.