Genomic Epidemiology of Clinical Isolates from Southern Israel.

Brucellosis, a zoonosis mainly transmitted by consumption of unpasteurized dairy products, is endemic in Southern Israel, mainly among the Bedouin Arab population. However, the genomic epidemiology of in this region has not yet been elucidated. A cohort of brucellosis cases ( = 118) diagnosed between 2017-2019 was studied using whole-genome sequencing (WGS).

Protein Biomarker Identification for the Discrimination of Field Isolates From the Rev.1 Vaccine Strain by MALDI-TOF MS.

Rev.1 is a live attenuated vaccine strain that is widely used to control brucellosis in small ruminants. For successful surveillance and control programs, rapid identification and characterization of isolates and reliable differentiation of vaccinated and naturally infected animals are essential prerequisites.

Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.

Mammalian Transducin-like enhancer of split (TLE) confer global repression of numerous target genes in conjunction with a myriad of DNA-binding repressors. These factors have a major role in the regulation of multiple signal transduction pathways. Evidence have been obtained regarding the possible role of some of these proteins in cancer.

Genomic Analysis of Natural Rough Rev.1 Vaccine Strains: Identification and Characterization of Mutations in Key Genes Associated with Bacterial LPS Biosynthesis and Virulence.

species are facultative intracellular bacteria that cause brucellosis, a zoonotic world-wide disease. The live attenuated Rev.1 vaccine strain is widely used for the control of brucellosis in the small ruminant population.