Publications by authors named "D Kniss"
Article Synopsis
- Pregnant individuals with obesity (BMI ≥ 30 kg/m) face longer labor times and have double the likelihood of needing a cesarean section compared to those with normal weight (BMI < 25 kg/m).
- A study aimed to determine if obesity affects myometrial contractility during labor by comparing samples from obese and normal-weight individuals after cesarean deliveries, involving 73 participants.
- Results showed no significant differences in contraction activity or oxytocin receptor expression between the two groups, although there was a noted reduction in prostaglandin receptor gene expression in the obese group, shedding light on the biological mechanisms linking maternal obesity to labor complications.
Article Synopsis
- Endothelial cells release signals that manage inflammation and restore blood vessel integrity, working alongside leukocytes and platelets to produce lipids that help resolve inflammation, such as Lipoxin A4 (LXA4).
- Aspirin, commonly used in cardiovascular conditions, inhibits the formation of proinflammatory lipids and encourages the production of anti-inflammatory mediators known as Aspirin-Triggered Lipoxins (ATL).
- The study found that cytokines increase certain signaling molecules in endothelial cells, influencing both pro-inflammatory and pro-resolving lipid production, and aspirin modulates these processes by affecting cyclooxygenase (COX) and lipoxygenase (LOX) pathways.
Objectives: The objective of this study is to evaluate whether there is an association between in-utero exposure to nicotine and subsequent hearing dysfunction.
Materials And Methods: Secondary analysis of a multicenter randomized trial to prevent congenital cytomegalovirus (CMV) infection among gravidas with primary CMV infection was conducted. Monthly intravenous immunoglobulin hyperimmune globulin therapy did not influence the rate of congenital CMV.
Objectives: To assess the association between aspirin and glycemic control in diabetic, pregnant patients, and the risk for aspirin resistance in those with poor glycemic control across gestation taking low-dose aspirin (LDA) for pre-eclampsia (PEC) prevention.
Study Design: We performed a secondary analysis of samples collected during the Maternal-Fetal Medicine Units trial of LDA for PEC prevention. A subset of insulin-controlled diabetic patient samples on placebo or 60 mg aspirin daily were evaluated.
Background: LDA triggers biosynthesis of endogenous anti-inflammatory molecules, aspirin-triggered 15-epi-lipoxin A (15-epi-LXA), which may counteract inflammatory process of preeclampsia (PE), and play role in LDA's mechanism of action in PE prevention in high-risk patients.
Objective: Investigate the effects of daily LDA on levels of 15-epi-LXA in pregnancies at high-risk for developing PE.
Materials And Methods: Secondary analysis of multi-centered randomized controlled trial investigating effects of daily LDA (60 mg) in high-risk pregnancies.