Publications by authors named "D Knights"
Objective: TRE is an emerging approach in obesity treatment, yet there is limited data on how it influences gut microbiome composition in humans. Our objective was to characterize the gut microbiome of human participants before and after a TRE intervention. This is a secondary analysis of a previously published clinical trial examining the effects of time-restricted eating (TRE).
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- Intestinal microbiota plays a crucial role in various diseases, and understanding diet's impact on it is essential for developing targeted therapies.
- A study analyzing meals and stool samples from 173 hospitalized patients found that higher caloric intake is linked to greater fecal microbiota diversity.
- The research indicates that consuming sweets or sugars while on antibiotics may disrupt the microbiome, suggesting that reducing sugar intake during such treatment could help protect gut health.
Article Synopsis
- Early life gut microbiomes significantly impact brain and immune system development, with probiotics suggested as a way to enhance health through microbiome modification.
- This study investigates the effects of maternal probiotic exposure during pregnancy and breastfeeding on inflammation in breastmilk, variations in maternal and infant microbiomes, and infant neurodevelopment.
- Results indicate that maternal probiotics are linked to lower breastmilk inflammation markers and changes in infant gut microbiome, as well as improved recognition memory responses in infants at 6 months old.
Article Synopsis
- Human milk is essential for infant nourishment, but there's limited understanding of how its composition affects infant health.
- A study examined the relationships between maternal genetics, milk gene expression, and the infant microbiome in 310 breastfeeding mother-infant pairs, identifying 482 genetic loci linked to milk characteristics.
- Findings revealed connections between milk components, like interleukin-6, and the gut bacteria of infants, highlighting the importance of genetics in lactation and its impact on maternal and infant health.
Article Synopsis
- Human cytomegalovirus (CMV) can be transmitted to infants through breast milk, having potential health impacts, especially on preterm and immunocompromised infants, while effects on healthy term infants are generally considered harmless.
- A study investigating breast milk from breastfeeding full-term mother-infant pairs revealed that CMV-infected milk showed changes in the metabolome and transcriptome, including the upregulation of a specific metabolic pathway.
- Findings indicate that CMV-associated changes in breast milk composition might influence infant gut microbiome and growth, with varying effects on infant weight related to components in the milk.