Publications by authors named "D Kevin Lester"

We examined DA activity in the medial prefrontal cortex (mPFC) and nucleus accumbens core (NAcc) in two Different Rat Models of Attention-Deficit/Hyperactivity Disorder: Spontaneously Hypertensive Rats (SHR) Versus Lphn3 Knockout Rats. We examined baseline stimulation-evoked phasic DA release, half-life, and DA autoreceptor (DAR) functioning in the mPFC and NAcc, as well as the response to nomifensine (10 mg/kg, IP), a DA transporter (DAT) blocker, on these measures in the NAcc. Both rat models were hypodopaminergic, with notable regional and mechanistic differences.

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Article Synopsis
  • The study aims to identify biochemical markers in individuals at risk of developing ALS or FTD due to the C9orf72 hexanucleotide repeat expansion (HRE).
  • Researchers compared levels of specific cerebrospinal fluid biomarkers in 48 asymptomatic C9orf72 HRE carriers, 39 controls, and various patient groups, finding increased levels of ubiquitin carboxyl-hydrolase isozyme L1 in carriers versus controls.
  • These elevated levels suggest early biochemical changes in C9orf72 HRE carriers that might be linked to disease mechanisms, enhancing understanding of disease progression and prevention strategies.
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Intussusception is an uncommon problem in the adult population. Interestingly, it is also a rare late complication after gastric bypass. We report the case of a 73-year-old woman with a history of Roux-en-Y gastric bypass (RYGB) in 2004 complicated by jejunal intussusception in 2011 for which a small bowel resection was performed.

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: While there is substantial literature on gender and research productivity, bearing mixed results, no study is available for suicidology. The present investigation fills this gap and focuses on an influential elite. : Data are taken from the Web of Science (WoS).

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