Publications by authors named "D Kereiakes"
Calcified plaque modification during percutaneous coronary revascularization.
Prog Cardiovasc Dis
December 2024
The presence and severity of calcified coronary plaque negatively impacts angiographic and clinical outcomes following percutaneous coronary intervention (PCI). Severe coronary calcification is associated with suboptimal stent delivery, deployment, apposition and expansion which can lead to in-stent restenosis and/or thrombosis. Severe coronary calcification is associated with incremental hazard for adverse clinical events, including death, during 5-10 years following PCI despite the use of new generation drug- eluting stents.
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- There is currently no FDA-approved dedicated transcatheter heart valve specifically for treating native aortic regurgitation.
- Ongoing clinical trials and compassionate use experiences in the U.S. offer some outcomes data, focusing on echocardiographic and clinical results one year post-procedure.
- A case study of a 28-year-old man treated with the J-Valve in 2019 shows promising long-term (5-year) outcomes, suggesting it could be a viable minimally invasive option for high-risk patients.
Article Synopsis
- * The J-Valve device, developed by JC Medical, shows promising outcomes, particularly in patients with complex anatomical challenges.
- * Two successful cases of transcatheter aortic valve replacement using the J-Valve were reported in patients who had significant aortic angulation.
Article Synopsis
- Coronary intravascular lithotripsy (IVL) is an effective method for stent implantation in severely calcified lesions, specifically those with calcified nodules (CNs).
- In a study of 155 patients, IVL demonstrated similar outcomes in terms of stent area and expansion, regardless of the presence of CNs, even though CNs had higher calcium volume and angle.
- The 2-year rate of target lesion failure was not significantly different between CN and non-CN lesions, suggesting that further research is needed to evaluate different treatment methods for these types of lesions.