Publications by authors named "D Keino"
Eltrombopag is used with first-line immunosuppressive therapy for adult aplastic anemia, although its practical utility in childhood remains unclear. We retrospectively analyzed the outcomes of pediatric patients who received eltrombopag in Japan. Of the 27 eligible patients, 23 (85%) were previously treated, and 15 (56%) had severe or very-severe disease.
View Article and Find Full Text PDFObjective: Chimerism analysis is an important post-transplant assessment for allogeneic hematopoietic stem cell transplant (HCT) recipients. Although various chimerism analysis techniques are already established, they are limited in terms of sensitivity, versatility, and turnaround time. Our objective was to develop a digital droplet polymerase chain reaction (ddPCR) assay for chimerism analysis using ABO gene polymorphisms as markers.
View Article and Find Full Text PDFArticle Synopsis
- * A novel FBXW7 variant was found in a patient with intellectual disability who also developed Wilms tumor, indicating a potential genetic link.
- * The study suggests that the tumor's development may follow a two-hit model, highlighting the need for further research to improve management and monitoring strategies.
Article Synopsis
- Silent inactivation (SI) of L-asparaginase (ASP) is a process where antibodies decrease ASP activity in patients without allergic reactions, affecting those with acute lymphoblastic leukemia (ALL) negatively.
- A clinical trial in Japan, named ALL-ASP19, measured ASP activity (ASA) to identify SI in newly diagnosed ALL patients, enrolling 110 participants but analyzing 66 after exclusions.
- The study found that the incidence of SI was low (4.5%) in Japan compared to other countries, and while all SI patients had antibodies, not all with antibodies experienced SI, indicating the importance of measuring ASA levels for effective treatment.
Article Synopsis
- IL10RA deficiency is a serious genetic disease that causes gut inflammation in babies and can be fatal, but a special type of treatment called hematopoietic cell transplantation (HCT) can help.
- In Japan, researchers looked at seven patients with this deficiency, including both new and previously known cases.
- All five patients who had HCT survived and got better, showing that this treatment should be done early for the best chance of recovery.