Publications by authors named "D Karas"
Developments in eye-tracking technology are opening up new possibilities for diagnosing patients in a state of minimal consciousness because they can provide information on visual behavior, and the movements of the eyeballs are correlated with the patients' level of consciousness. The purpose of this study was to provide validation of a tool, based on eye tracking by comparing the results obtained with the assessment obtained using the Coma Recovery Scale-Revised (CRS-R). The mul-ti-center clinical trial was conducted in Poland in 2022-2023.
View Article and Find Full Text PDFNature provides us with a rich source of compounds with a wide range of applications, including the creation of innovative drugs. Despite advancements in chemically synthesized therapeutics, natural compounds are increasingly significant, especially in cancer treatment, a leading cause of death globally. One promising approach involves the use of natural inhibitors of checkpoint kinase 2 (Chk2), a critical regulator of DNA repair, cell cycle arrest, and apoptosis.
View Article and Find Full Text PDFBackground: This project aimed to introduce substance use screening, using the CRAFFT (Car, Relax, Alone, Forget, Family/Friends, Trouble) screening tool, into the routine care of adolescents using quality improvement strategies and tools.
Methods: We expanded a single-site project showing the successful introduction of CRAFFT screening into adolescent care to include the entire 34-site primary care network of a children's hospital in Northeastern Ohio. We deployed quality improvement methodology to facilitate the acceptance and use of the screener.
Article Synopsis
- Adolescents with high body mass index are at a greater risk for health issues like diabetes and fatty liver disease, but only 20% currently receive proper screening.
- A quality improvement project was launched to enhance screening rates through provider education, clinical decision support, and regular feedback.
- Between March and December 2022, screening rates significantly increased from 19.5% to 58%, helping to identify many patients at risk for chronic diseases.
Article Synopsis
- * Researchers created guidelines and a standardized order set for primary care providers to improve the diagnosis and management of urinary tract infections (UTIs). This aimed to support appropriate antibiotic prescriptions.
- * Between March 2018 and March 2020, the use of the recommended antibiotic cephalexin rose significantly while the less effective trimethoprim-sulfamethoxazole fell sharply, showing that the new approach effectively improved prescribing practices.