Publications by authors named "D Kahne"
Biofilm formation by is triggered by a drop in the levels of a cyclic dinucleotide.
Proc Natl Acad Sci U S A
December 2024
The bacterial pathogen forms multicellular communities known as biofilms in which cells are held together by an extracellular matrix principally composed of repurposed cytoplasmic proteins and extracellular DNA. These biofilms assemble during infections or under laboratory conditions by growth on medium containing glucose, but the intracellular signal for biofilm formation and its downstream targets were unknown. Here, we present evidence that biofilm formation is triggered by a drop in the levels of the second messenger cyclic-di-AMP.
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- The BAM complex helps fold different shapes and sizes of β-barrel proteins into cell membranes.
- Researchers created a new method to see how these proteins fold while they are being helped by BAM.
- They found that even though the proteins are different, they get stuck at similar points during folding, showing that BAM helps overcome common folding problems.
Nonvesicular lipid trafficking pathways are an important process in every domain of life. The mechanisms of these processes are poorly understood in part due to the difficulty in kinetic characterization. One important class of glycolipids, lipopolysaccharides (LPS), are the primary lipidic component of the outer membrane of Gram-negative bacteria.
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