Publications by authors named "D K Yanagisawa"

Purpose: This multi-institutional observational study aimed to assess the incidence, severity, and impact of radiotherapy-related late toxicities of the cervical skin and soft tissue in head and neck cancer patients. We also explored patient interest in fat grafting as a potential treatment for skin and soft tissue sequelae.

Methods: This study was conducted across 19 institutions in Japan.

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Plasmalogens are brain-enriched phospholipids with a vinyl-ether bond at the -1 position between the glycerol backbone and the alkyl chain. Previous studies have suggested that plasmalogens modulate locomotor activity, anxiety-like behavior, and cognitive functions in rodents; however, the specific moieties contributing to behavioral regulation are unknown. In this study, we examined the behavioral modulation induced by specific phospholipid moieties.

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Article Synopsis
  • The menopausal transition involves complex changes in the brain and metabolism that can lead to cognitive deficits, as observed both in humans and rodent models.
  • In this study, young female rats were given a substance (VCD) to simulate menopause, and researchers examined their behavior, brain structure, metabolism, and hormonal changes over time.
  • Results indicated that the rats experienced reduced spatial learning and memory, decreased hippocampal glucose uptake, and hormonal imbalances, which suggest that menopause-related ovarian function loss can negatively affect cognitive abilities and brain metabolism.
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Epidemiological studies suggest that poor nutrition during pregnancy predisposes offspring to the development of lifestyle-related noncommunicable diseases and psychiatric disorders later in life. However, the molecular mechanisms underlying this predisposition are not well understood. In our previous study, using rats as model animals, we showed that behavioral impairments are induced by prenatal undernutrition.

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