The effects of volunteering on loneliness among lonely older adults: the HEAL-HOA dual randomised controlled trial.

Background: Previous randomised controlled trials have largely relied on self-reported volunteer work to assess the effects of volunteering and have rarely provided structured volunteering activities during the intervention period. The present study aimed to investigate the effects of social volunteering work over 12 months on loneliness among older adults during the COVID-19 pandemic.

Methods: A dual randomised controlled trial was done in Hong Kong to investigate the long-term effects of telephone-delivered psychosocial interventions by older Chinese volunteers who were screened as lonely, for older adult recipients who had low income, lived alone, felt lonely, and were digitally excluded.

Direct STAT3 and STAT5 Inhibition Overcomes Treatment Resistance in a Murine Derived In Vitro Model of Acute Lymphoblastic Leukaemia driven by ETV6::JAK2.

INTRODUCTION ETV6::JAK2 is a fusion known to drive Acute Lymphoblastic Leukaemia (ALL) in the presence of other genomic lesions which define the JAK/STAT class of Philadelphia-like Acute Lymphoblastic Leukaemia (Ph-like ALL). Ph-like ALL comprises approximately 15% of ALL. Patients with mutations or gene fusions signaling through the JAK/STAT pathway have particularly poor prognosis.

Detection of Movement and Lead-Popping Artifacts in Polysomnography EEG Data.

Polysomnography (PSG) measures brain activity during sleep via electroencephalography (EEG) using six leads. Artifacts caused by movement or loose leads distort EEG measurements. We developed a method to automatically identify such artifacts in a PSG EEG trace.

Lay health coaching intervention for older adults with chronic diseases: study protocol for a pragmatic randomised controlled trial.

Background: A large proportion of older adults suffer from chronic diseases. Health coaching is a promising intervention that enhances individuals' health knowledge and supports changes in health behaviours. Even though health professionals usually conduct health coaching interventions, lay health workers from different backgrounds account for a growing segment of health coaches over the years.

Direct traction MR imaging of the wrist: practical experience.

Objective: To study the effect of direct wrist traction on patient pain and joint distraction on MRI.

Materials And Methods: 291 patients (109 males, 182 females; mean age, 45.8 years) who underwent wrist MRI between November 2019 and September 2024 were studied (152 patients with traction, 139 patients without traction).