Publications by authors named "D K Roukas"
Article Synopsis
- The number of dementia cases in Europe is currently 7.7 million and is expected to double by 2050, leading to increased caregiver burden and significant mental health challenges, particularly for women.
- A systematic review of recent studies showed that caregivers experience heightened anxiety and depression, which is exacerbated by factors like low socioeconomic status and is often linked to burnout and decreased quality of life.
- Addressing these issues through tailored support, training, and policy improvements could help reduce caregiver burden and enhance the quality of care for dementia patients.
Background/aim: Concerning primary central nervous system neoplasms, meningiomas demonstrate the most common type in adults worldwide. Deregulation of apoptotic pathways in malignancies, including meningiomas, is correlated with chemoresistance and poor prognosis. Caspases represent crucial proteins that induce cell apoptosis.
View Article and Find Full Text PDFIntroduction: Coronary artery disease (CAD) is a major and multifaceted health problem but also the first cause of death in modern Western societies. Furthermore, myocardial infarction (MI) constitutes a challenge for analysis in the field of molecular mechanisms, early diagnosis and therapeutic approaches, as its incidence increases every year worldwide. Concerning the histopathological diagnosis in the corresponding cases, a variety of immunohistochemistry (IHC) markers and methods are available to support conventional histology diagnosis.
View Article and Find Full Text PDFIntroduction: Onset and progression of malignant tumors is a multistep process including a variety of gross chromosomal and specific genes' deregulation. Among oncogenes that are frequently altered in solid and also in hematological malignancies, the C-myc (gene locus: 8q24.21) plays a pivotal role.
View Article and Find Full Text PDFArticle Synopsis
- PTEN is a tumor suppressor gene that regulates key cell signaling pathways and is often altered in various cancers, including salivary gland carcinomas (SGCs).
- SGCs show diverse histopathological characteristics and genetic imbalances, affecting their behavior and treatment responses.
- The review focuses on how PTEN deregulation influences the development and progression of SGCs, highlighting its importance in targeted therapies.