Publications by authors named "D K Pavlov"
Article Synopsis
- - The study compared digital phenotyping with traditional monitoring methods in 800 patients with arterial hypertension over three years, focusing on lifestyle interventions aimed at improving various health metrics.
- - Significant improvements were observed in the experimental group, including a notable reduction in systolic blood pressure (by 10 mmHg), heart rate (by 5 beats per minute), and stress levels, alongside increases in physical activity and sleep quality.
- - The research highlights the effectiveness of comprehensive lifestyle changes in managing hypertension and suggests the need for further studies to optimize these intervention strategies for better societal health outcomes.
The aim of the present work was to investigate some of the molecular mechanisms and targets of the anticancer action of the bioflavonoid fustin isolated from the heartwood of Scop. in the triple-negative breast cancer cell line MDA-MB-231. For this purpose, we applied fluorescence microscopy analysis to evaluate apoptosis, necrosis, and mitochondrial integrity, wound healing assay to study fustin antimigratory potential and quantitative reverse transcription-polymerase chain reaction to analyze the expression of genes associated with cell cycle control, programmed cell death, metastasis, and epigenetic alterations.
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- - The study aimed to assess the safety, tolerability, pharmacokinetics, and effectiveness of sasanlimab, a monoclonal antibody targeting PD-1, in treating participants with advanced cancers, including a focus on non-small-cell lung cancer.
- - An open-label design was used, with Phase Ib involving dose escalation and expansion in Asian participants, while Phase II included a global trial randomizing participants to receive either 300 mg every 4 weeks or 600 mg every 6 weeks.
- - Results indicated that Phase Ib had no dose-limiting toxicities and Phase II showed manageable grade 3 treatment-related adverse events, with confirmed response rates of 26.8% and 15.0%
Nonsymmetric diarylethenes with an additional "stiff" cyclohexenol ring undergo various types of tandem transformations launched by light-induced 6π-photocyclization. Among these, there are two novel reactions (formal [1,3]-H migration and complete aromatization to an anthracene derivative) as well as photorearrangement and formal methane elimination. This diverse reactivity demonstrates the great potential of --diarylethenes in synthetic photochemistry.
View Article and Find Full Text PDFNuclear homeostasis requires a balance of forces between the cytoskeleton and nucleus. Mutations in the gene, which encodes the nuclear envelope proteins lamin A/C, disrupt this balance by weakening the nuclear lamina. This results in nuclear damage in contractile tissues and ultimately muscle disease.
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