Publications by authors named "D K Papadimitriou"
Background & Aims: The dynamics of HBV viral load (VL) in patients with chronic hepatitis B (CHB) on nucleos(t)ide analogue (NA) treatment and its relationship with liver disease are poorly understood. We aimed to study longitudinal VL patterns and their associations with CHB clinical outcomes.
Methods: Utilising large scale, routinely collected electronic health records from six centres in England, collated by the National Institute for Health and Care Research Health Informatics Collaborative (NIHR HIC), we applied latent class mixed models to investigate VL trajectory patterns in adults receiving NA treatment.
Editorial: Advances in the treatment of sexual precocity and infertility.
Front Endocrinol (Lausanne)
November 2024
Background: Cardiac troponin is commonly raised in patients presenting with malignancy. The prognostic significance of raised troponin in these patients is unclear.
Objectives: We sought to investigate the relation between troponin and mortality in a large, well characterised cohort of patients with a routinely measured troponin and a primary diagnosis of malignancy.
Article Synopsis
- - This study focused on classifying patients with heart failure (HF) and preserved or mildly reduced ejection fraction into specific phenogroups to improve targeted treatment options.
- - Researchers analyzed data from over 2,000 patients across five UK hospitals using advanced machine learning techniques and found three distinct phenogroups, each with different clinical traits and survival outcomes.
- - The findings revealed that survival rates declined from the first phenogroup to the third, highlighting the importance of phenogroup membership in predicting survival better than traditional factors, though it did not predict hospitalisation for HF.