Exploring nalbuphine loaded chitosan nanoparticles for effective pain management through intranasal administration: a comparative study.

Background: Intranasal drug delivery shows potential for brain access via olfactory and trigeminal routes.

Purpose: This work aimed to ensure brain availability of nalbuphine via the nasal route.

Method: Chitosan based nanoparticles loaded with nalbuphine were successfully prepared using ionic gelation method and characterised.

AI based UPQC control technique for power quality optimization of railway transportation systems.

Metro trains have non-linear load characteristics, which means that the power sent to them gets distorted. Problems are caused by changes in power, swells, harmonics, and other disturbances. In this research, an artificial intelligence-driven control method was used on a unified power quality conditioner (UPQC) to help reduce power quality problems and improve power quality.

Protective Effect of Organ Preservation Fluid Supplemented With Nicorandil and Rutin Trihydrate: A Comparative Study in a Rat Model of Renal Ischemia.

Objectives: The objective of organ preservation is sustained viability of detached/removed/isolated organs and subsequent successful posttransplant outcomes. Nicorandil (an ATP-sensitive potassium channel opener) is an efficacious agent to preserve lungs and heart. Rutin trihydrate (an antioxidant) inhibits free radical-mediated cytotoxicity and lipid peroxidation.

Melatonin-Caffeine Combination Modulates Gamma Radiation-induced Sperm Malformations in C57BL/6 Male Mice at Sublethal Dose of Gamma Radiation.

Aims: The aim of this study was to assess the protective effect of the melatonin-caffeine combination against γ radiation-induced alterations in the morphological characteristics of sperms.

Settings And Design: C57BL/6 male mice ( = 30) were randomly divided into five groups: control, radiation (2 Gy), melatonin (100 mg/kg body wt.) + radiation (2 Gy), caffeine (30 mg/kg body wt.

Intranasal solid lipid nanoparticles for management of pain: A full factorial design approach, characterization & Gamma Scintigraphy.

Pain is a noxious stimulus caused due to tissue damage and varies from mild to severe. Nalbuphine (NLB) is an approved, inexpensive, non-controlled, opioid agonist/antagonist analgesic used worldwide in various clinical settings for pain management. The current study aims to formulate NLB loaded solid lipid nanoparticles (SLNs) using solvent injection technology.