[Effectiveness of metabolic therapy in elderly patients with discirculatory encephalopathy and moderate cognitive disorders.].

The effectiveness of neurometabolic therapy in patients with various stages of discirculatory encephalopathy was assessed according to the severity of cognitive impairment. Using a number of studies [clock drawing test, MMSE, Spielberger-Hanin, Bourdon test and cognitive evoked potentials (P300 peak)], cognitive functions of 60 elderly patients (mean age - 61,3±12,4 years) with various degrees of chronic head ischemia were analyzed brain and discirculatory encephalopathy of the I-III stages. Depending on the treatment regimen, patients were divided into 2 groups: 34 (the main group) received Cytoflavin in the treatment regimen: 2 tablets 2 times/day for 2 months.

Analysis of K-ras codon 12 and TP53 mutations in patients with advanced colorectal carcinoma.

Background: Colorectal cancer (CRC) is one of the most common types of cancer, affecting 3 - 5% of the global population. K-ras protooncogene and TP53 tumour suppressor gene mutations are among the most common genetic alterations detected in advanced colorectal tumours.

Objective: To investigate the role of K-ras codon 12 and TP53 exons 5 - 9 mutations in late-stage CRC patients.

[Event-related potentials in moderate cognitive impairment in patients with chronic cerebral ischemia treated with cytoflavin].

Authors compared cognitive functions in 60 patients (main group) with different stages of discirculatory encephalopathy (DE), I, II and III stages. A comparison group included 10 age-matched normals without DE. All patients underwent a clinical-neurological investigation and performed neuropsychological tests (MMSE, the Clock drawing test, Burdon probe) and Spilberger-Khanin test.

[Acute rheumatic fever and rheumatic heart disease: immunological studies].

A total of 216 patients with rheumatic fever and rheumatic heart from the Institute of Rheumatology and 126 patients with rheumatic heart diseases alone from the Center of Cardiosurgery were clinically and immunologically studied. The immunological study included the detection of b-hemolytic group A streptococcus, O-antistreptolysin, the measurement of C-reactive protein, immunoglobulins, C3, C4, Ciq-binding, anticardiolipin antibodies, etc. The findings indicated that the secondary penicillin prophylaxis prevents streptococcal pharyngitis and recurrence of acute rheumatic fever after 5 years.

[The neuroendocrine system and specific factors of immunity in pesticide poisoning].

Experiments performed effects of chronic administration of organophosphate pesticide "Antio" (dose 1/100 LD50) on specific factors of immunity and corticosterone (CS) levels in the blood. Adult male Wistar rats were used in all experiments. The immunological indexes were increased, CS levels were decreased.