Molecular characterization of a novel photoperiod-insensitive allele Ppd-B1a.3 and its effect on heading date in Chinese wheat (Triticum aestivum) cultivar Qingchun 37.

Breeders adjust wheat heading dates to improve regional adaptability and reduce or mitigate yield losses caused by meteorological disasters, pests and diseases. The Ppd-1 genes play a crucial role in determining wheat sensitivity to changes in day-length and serve as key regulators of heading dates once the vernalization requirement is satisfied. In this study, we identified a new allelic variant of the promoter region, Ppd-B1a.

Network pharmacology, molecular docking, and experimental verification to reveal the mechanism of colquhounia root tablet in the treatment of diabetic nephropathy.

Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes mellitus. Colquhounia Root Tablet (CRT), one of the Tripterygium wilfordii Hook F. (TwHF)-based therapeutics, has exhibited various functions in DN.

The Cardioprotective Effect of Ginseng Derived Exosomes via Inhibition of Oxidative Stress and Apoptosis.

Ginsenosides possess potential protective effects against cisplatin (CDDP)-induced toxicity, but the limited bioavailability of ginsenosides hampered their therapeutic application. Ginseng exosomes (G-Exo), which are active ingredients in ginseng, exhibit excellent biocompatibility and low immunogenicity. Here, G-Exo were isolated from ginseng roots through a combination of ultracentrifugation and sucrose gradient centrifugation techniques.

Lysozyme/Tracheal Antimicrobial Peptide-Based Tissue-Specific Expression Antimicrobial Plasmids Show Broad-Spectrum Antibacterial Activities in the Treatment of Mastitis in Mice.

The use of antibiotics is the preferred therapy for bacterial diseases. However, overusing antibiotics has led to the development of antibiotic resistance in bacteria, which is now a major public health concern. Therefore, in this study, the performance of lysozyme (LYZ)/tracheal antimicrobial peptide (TAP)-based tissue-specific expression antimicrobial plasmids (TSEAP) have been evaluated in the treatment of mastitis in mice.