Publications by authors named "D K C Tay"
Background: The COVID-19 pandemic heightened anxiety levels globally, disproportionately affecting low-and middle-income countries (LMICs). Physical activity (PA) has shown potential to alleviate mental health challenges, including anxiety. This study explores the relationship between PA and anxiety among Tanzanian adults during the pandemic, examining whether self-reported health status moderates this relationship and identifying demographic variations.
View Article and Find Full Text PDFExploring the molecular correlates of metabolic health measures may identify their shared and unique biological processes and pathways. Molecular proxies of these traits may also provide a more objective approach to their measurement. Here, DNA methylation (DNAm) data were used in epigenome-wide association studies (EWASs) and for training epigenetic scores (EpiScores) of six metabolic traits: body mass index (BMI), body fat percentage, waist-hip ratio, and blood-based measures of glucose, high-density lipoprotein cholesterol, and total cholesterol in >17,000 volunteers from the Generation Scotland (GS) cohort.
View Article and Find Full Text PDFBackground And Aims: The interaction of immune checkpoint inhibitors (ICI) and concomitant medications such as antibiotics, metformin, statins, beta-blockers, proton pump inhibitors (PPIs), nonsteroidal anti-inflammatory drugs (NSAIDs), and low-dose aspirin has been studied in other malignancies. Our study aims to investigate the relationship between these medications and ICI efficacy in patients with advanced hepatocellular carcinoma (aHCC).
Methods: A retrospective review of patients who received at least one dose of ICIs between May 2015 and November 2019 was performed.
Article Synopsis
- The study investigates financial toxicity among advanced cancer patients receiving immunotherapy and their caregivers, highlighting how this financial burden relates to expensive treatments and external factors like inflation and the COVID-19 pandemic.
- Interviews were conducted with 16 patients and 10 caregivers to assess their experiences, revealing themes around sources, buffers, and consequences of financial toxicity.
- Findings indicate that those living in non-metropolitan areas face amplified financial challenges due to rising costs, while social support can help mitigate these impacts, particularly for younger and privately insured patients.
Introduction: Unicompartmental Knee Arthroplasty (UKA) has become popular due to faster recovery and improved range of motion. However, concerns have been made regarding increased risk of early failure. Furthermore, the use of Enhanced Recovery After Surgery (ERAS) protocols have shown to allow faster return to activities, improved satisfaction, and reduced complication rates.
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